either go up north from LA or go down south from SF.
my recommendation would be (from LA):
- get on PCH at the end of 10 freeway at Santa Monica, go north.
- stop by Pepperdine, my alma mater

- stop by Zuma Beach (right after you pass Kanan Road), check out the beach, turn around just a bit.
- go north on Kanan, enjoy the winding road bit, jump on 101N at Agoura Hills
- connect back to HWY 1 at San Luis Obispo, go towards Hearst Castle
- do the coast drive
- connect to 17N at santa cruz - enjoy the winding road, connect back to the 101.
or you can keep going on HWY1 to your heart's desire, but by this point i've just about had enough beach. a stop over monterey and do the aquarium is a good idea as well.
i used to the above trip 2 ~ 3 times a year growing up in LA